tPA dosing

  • tPA dosing

    Posted by Angie Blackwell on May 14, 2019 at 6:39 pm

    ​At your institutions, how do you dose tPA for clearing occluded CVADs?
    Option A:

    1. Under 30 kg = 110% internal lumen volume of catheter not to exceed 2 mg/2 mL
    2. > 30 kg = 2 mg/2 mL per lumen

    OR

    Option B:
    110% internal lumen volume of catheter not to exceed 2 mg/2 mL

    We currently dose by weight (option A), but are looking at evidence supporting the use 110% of lumen volume. It appears to be just as effective but the dosage is smaller. As we consider changing policy, would love to hear what other institutions are doing.
    Thank you!

    ——————————
    Angie Blackwell,
    MSN, RN, CNS, CPON
    Orange County, CA
    United States
    ——————————

    Mary Lynn Rae replied 4 years, 11 months ago 2 Members · 1 Reply
  • 1 Reply
  • Mary Lynn Rae

    Member
    May 15, 2019 at 10:42 am

    We use option B for external CVCs (110%); ports we always use 2 mg/2mL

     

    Thanks,

    Mary Lynn

    Mary Lynn Rae, MSN, RN, CPHON

    NPD Practitioner/Clinical Educator Hem/Onc/SCT

    Ann & Robert H. Lurie Children’s Hospital of Chicago

    T 312.227.4224 | mlrae@luriechildrens.org | luriechildrens.org

    225 East Chicago Avenue, Box 248, Chicago, Illinois 60611-2991

    APHON Chicago Chapter President

    image006.jpg@01D455CA.162671C0

     

    ——Original Message——

    ​At your institutions, how do you dose tPA for clearing occluded CVADs?
    Option A:

    1. Under 30 kg = 110% internal lumen volume of catheter not to exceed 2 mg/2 mL
    2. > 30 kg = 2 mg/2 mL per lumen

    OR

    Option B:
    110% internal lumen volume of catheter not to exceed 2 mg/2 mL

    We currently dose by weight (option A), but are looking at evidence supporting the use 110% of lumen volume. It appears to be just as effective but the dosage is smaller. As we consider changing policy, would love to hear what other institutions are doing.
    Thank you!

    ——————————
    Angie Blackwell,
    MSN, RN, CNS, CPON
    Orange County, CA
    United States
    ——————————

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