Reply To: neuroblastoma and isotretinoin aggression side effects management

  • Deborah Lafond

    October 7, 2020 at 2:53 pm

    You could consider using Risperidone. Start low and titrate up to effect.

    These are always challenging situations. Thank you for advocating for him!

    Debbie Lafond, NP

    Sent from my iPhone

    Original Message:
    Sent: 10/7/2020 11:20:00 AM
    From: Kristi Geib
    Subject: neuroblastoma and isotretinoin aggression side effects management

    We are treating a 7yo autistic child for neuroblastoma.  He is having a very difficult time with isotretinoin therapy.  He tolerated his first cycle without troubles, but in his 2nd cycle he developed significant behavior changes, including intense aggression – particularly to his younger sibling.   We are trying clonazepam with his isotretinoin course during this 3rd cycle, but just day 2 into it, he is already worse than previous.   Anyone have ideas to help this otherwise really sweet boy tolerate his isotretinoin therapy better?   Really appreciate the input.

    Kristi Geib, CPNP,CPON,MSN,RN
    UNC Chapel Hill
    Pediatric Hematology/Oncology