Reply To: Erwinia Asparaginase

  • Mary Lynn Rae

    November 12, 2020 at 4:34 pm
    We went back to IM specifically for that reason; too much N/V

    Mary Lynn
    Mary Lynn Rae, MSN, RN, CPHON, NPD-BC
    NPD Practitioner/Clinical Educator:  Hem/Onc/SCT (LC17/LC18)
    Ann & Robert H. Lurie Children’s Hospital of Chicago
    225 E. Chicago Avenue
    Chicago, Illinois  60611
    Phone:  312-227-4224
    Pager:  312-227-4000, ask for pager 74224

    Original Message:
    Sent: 11/12/2020 4:30:00 PM
    From: Holly Remington Kubaney
    Subject: RE: Erwinia Asparaginase

    HI Elizabeth!

    There is much more nausea/vomiting associated with IV Erwinaze vs IM ERwinaze!  We have even had some children ask to go back to the IM route.  Consider multiple anti-emetic pre-meds.  It may be easier to manage since your patient will be inpatient. 
    Hope that helps,

    Holly R. Kubaney, MSN, PPCNP-BC, CPHON

    Pediatric Nurse Practitioner

    Dell Children’s Blood and Cancer Center
    t: 512-628-1900        m: 512-350-3754

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    Original Message:
    Sent: 11/12/2020 4:09:00 PM
    From: Elizabeth Sonnenblick
    Subject: Erwinia Asparaginase

    We will be giving Erwinia asparaginase IV instead of IM for the first time next week as per the option in COG AAML1831.  Are there any different monitoring guidelines, has anybody seen an increase in adverse reactions with the IV route?  There is the option to give IM in the protocol, but if it’s all the same I’d rather not give an IM injection

    Elizabeth Sonnenblick, CPHON,CPNP,MSN,RN
    St Joseph’s Regional Medical Center
    Paterson, NJ
    United States