Reply To: Asparaginase – premedications and TDM

  • Elise Oberman

    November 16, 2021 at 4:35 pm



    We are in the process of updating our SOP or else I would send to you – however, here is a nice paper that we are using as a model! In terms of the lab monitoring, we generally get a level one week after the first dose in a given cycle (balancing detection of silent inactivation with cost effectiveness).




    Elise Oberman

    Original Message:
    Sent: 11/16/2021 3:52:00 PM
    From: Jennifer Toth
    Subject: RE: Asparaginase – premedications and TDM

    Hi Rosemary-
    We don’t have an SOP for this, but here is an algorithm that was shared in one of the presentations at the recent APHON conference that I found to be a helpful guide! 

    Jennifer Toth, MSN, CPHON, CPNP-AC
    Nurse Practitioner
    Pediatric, Adolescent, and Young Adult Hematology/Oncology
    MedStar Georgetown University Hospital
    Washington, DC
    Original Message:
    Sent: 11-14-2021 09:07 PM
    From: Rosemary Burnett
    Subject: Asparaginase – premedications and TDM

    Hello All,

    My group is currently interested in changing their practice to include premedication for all asparaginase infusions and therapeutic drug monitoring to monitor subsequent asparaginase activity.  We would like to work on an SOP for the division here. I was wondering if anyone would mind sharing their institutions current SOP?

    Thanks in advance!

    Rosemary Burnett, PNP-BC
    Rochester, NY
    United States