Reply To: Asparaginase Premedications

  • Amy Lahey

    December 23, 2021 at 4:08 pm

    We used to premedicate PEG only (not Erwinia or Rylaze) with benadryl, famotidine, and hydrocortisone. A review of our institutional data showed no difference in reaction rates compared to historical data without premeds, so we no longer premedicate for PEG.

    Amy Lahey, PNP
    Leukemia/Lymphoma Nurse Practitioner
    Tucker, GA
    United States
    Original Message:
    Sent: 12-20-2021 10:09 PM
    From: Megan Wegter
    Subject: Asparaginase Premedications

    My institution is looking into pegaspargase pre-medications. We currently premedicate with pepcid and benadryl however, we are considering adding hydrocortisone as well. Can others speak to what premedications are used at their institutions for pegaspargase (erwinia and rylaze also included)?

    Thank you,

    Meg Wegter, DNP, CPNP-PC
    Nurse Practitioner – Pediatric Oncology
    MACC Fund Center for Cancer and Blood Disorders

    Megan Wegter, DNP
    Milwaukee, WI
    United States