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Reply To: procedure for clotting/clumping during infusion of HPCs
We gravity drip our cells with a 170-260 micron filter set. We put a stopcock on the end with an empty 10 mL syringe if the cells get stuck.
——————————————- Mary Lynn Rae Ann & Robert H. Lurie Children’s Hospital of Chicago Chicago, IL United States ——————————————-
——————————————- Original Message: Sent: 10-02-2014 12:41 PM From: Tobi Reisig Subject: procedure for clotting/clumping during infusion of HPCs
Have other centers had issues with clotting or clumping of the cells during infusion of fresh or cryopreserved PBSCs or cord infusions. For several years our procedure has been to closely monitor the clottin/clumping in the line and when it is at the “y” we disconnect the reaction line and aspirate the clots/clumps with a syringe. This does not happen very often but we do occasionally see this. I have been looking at replacing this procedure with a 170 micron filter that can be added to the end of the line to catch any clotting/clumping of cells in the line. The filter is made by ICU medical. Wondering if others have seen this or had this issue and what they do? Anyone else add a 170 or larger filter. If clotting/clumping is detected in the bag before spiking we add a 170-260 micron blood filter.
——————————————- Tobi Reisig Alberta Children’s Hospital Calgary, AB Canada ——————————————-