Reply To: Stem Cell Infusion Tubing

  • Amy Spence

    September 10, 2018 at 5:59 pm

    I actually worked with ICU medical to create a tubing that will work for our cellular therapy products. It has a Y at the top and also a built in stop cock a few inches up from the patient for troubleshooting. This allows a rinse, flush and troubleshooting all while staying connected to the patient. We have recently requested to change the pinch clamp on the main tubing to a roller clamp as some RNs were having problems reaching up to the roller clamp(s) on the Y lines. Awaiting to see if they can make that one.

    Amy Spence MS, RN, CPN, CPON®
    Advanced Nursing Education Specialist
    Cancer & Blood Disorders Institute
    Johns Hopkins All Children’s Hospital
    St. Petersburg, Florida
    Original Message:
    Sent: 02-20-2018 03:04 PM
    From: Dyane Bunnell
    Subject: Stem Cell Infusion Tubing

    ​I am interested in learning about the tubing that centers are using for infusion of hematopoietic stem cells via a bag.
    For years, our center has been using a Y-type gravity infusion set (with 2 bag spikes — one for saline, one for stem cells) without a filter. This set up has allowed us to “rinse” the stem cell bag with saline to remove/infuse any remaining stem cells at the end of the infusion.

    I recently learned that this particular tubing set is being discontinued, prompting me to ask about everyone’s practice of infusing stem cells from a bag.

    According to the AABB Circular of Information for the Use of Cellular Therapy Products, it is permissible to use a filter (170-260 micron) designed to remove clots and (obviously) NOT a filter that is designed to remove leucocytes. However, I know that most centers are reluctant to use any kind of filter.

    Here are my questions:
    1. Do you use a Y-type set up to infuse stem cells? If so, what brand/manufacturer?
    2. Do you “rinse” the stem cell bag at the completion of the infusion?
    3. Does the tubing set you use have a filter?
    4. Anything else I should know about your practice of stem cell infusions?

    Many thanks in advance for your responses!


    Dyane Bunnell, APRN,CPON,MSN,RN
    Clinical Nurse Specialist
    Wilmington, DE
    United States