Reply To: Peridex (Chlorhexidine Mouthwash) with Mucositis

  • Mary Lynn Rae

    June 25, 2018 at 6:31 pm



    We stopped using Peridex several years ago since it contains alcohol and it was too painful for the kids to use with Mucositis.  We use Biotene


    Mary Lynn

    Mary Lynn Rae, MSN, RN, CPHON

    Clinical Educator Hem/Onc/SCT & VAT

    Ann & Robert H. Lurie Children’s Hospital of Chicago

    T 312.227.4224 | |

    225 East Chicago Avenue, Box 248, Chicago, Illinois 60611-2991

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    ——Original Message——

    Hi everyone,

    It is very challenging for certain kids to manage Peridex, especially once mucositis begins. Our current practice does not remove Peridex once mucositis is appreciated, so staff will continue to promote its use, often presenting challenges. I’m biased toward believing that more thorough oral care (covering more areas more frequently with even sterile saline or a like component) could be as effective, if not moreso, than scant Peridex with struggling.

    I have not found literature that supports the use of Peridex as a treatment for mucositis, or to support its use once ulceration begins; only fair evidence to support its use as a preventive measure. 

    Are there other facilities that use Peridex continuously?

    Are there differences in treatment for your transplant population?

    Thanks for the info.

    Chris Donaghey, MSN, RN, PCNS-BC, CPN, CPHON
    Clinical Nurse Specialist – Riley Cancer Care
    Riley Hospital for Children at IU Health
    Indianapolis, IN