Reply To: cetirizine for premed?

  • Marge Ancliffe

    January 19, 2023 at 3:28 pm

    We routinely use Cetirizine for pre-medication for blood/blood products and chemotherapy.  We dose at 0.25mg/kg to a max of 10mg per dose.  Our hospital has significantly lessened the use of IV Diphenhydramine due to the unpredictable side effect profile – although we can still access it on our formulary.  Since we implemented Cetirizine pre-meds, I can count on one hand how many times I’ve needed to order Diphenhydramine!

    Marge Ancliffe, NP
    Pediatric Oncology NP
    IWK Health
    Halifax, NS
    Original Message:
    Sent: 01-19-2023 02:18 PM
    From: Monica Ploof
    Subject: cetirizine for premed?

    I have successfully used cetirizine in patients who had previous reactions while receiving blood products, IVIG, and chemotherapy. These patients were able to tolerate infusion successfully with cetirizine as pre-med. Reasons for not using Benadryl were due to excessive aggressive behavior, tearful, extreme pruritis or generalized intolerance of the drug.


    Monica M. Ploof CPNP

    Pediatric Hematology/Oncology

    University of Vermont Medical Center


    Original Message:
    Sent: 1/19/2023 2:29:00 PM
    From: Jami Gattuso
    Subject: cetirizine for premed?

    Does anyone use cetirizine as a pre-med for chemo or blood products?  Thanks, Jami

    Jami Gattuso, CPON,MSN,RN
    Nursing Research Specialist
    Memphis, TN
    United States