Reply To: Vaccines S/P CAR-T

  • Leticia Valdiviez

    August 9, 2018 at 11:12 pm

    I posed this question to one of my attending physicians and here was her response: 

    If the CARs are persisting and the patient has B cell aplasia, then vaccines will not be efficacious. Once you have documented good immune reconstitution in terms of B cell numbers and the patient is no longer IVIG-dependent, then we can re-immunize.

    Letty Valdiviez, MSN, RN, CPHON
    CAR T Coordinator
    Children’s Hospital Los Angeles
    Original Message:
    Sent: 08-08-2018 02:09 PM
    From: Michelle Gillard
    Subject: Vaccines S/P CAR-T

    ​Hello from Phoenix,
    Since many of you are now doing CAR-T at your institutions, I’m wondering if you have an SOP or plan for vaccines s/p CAR-T infusion? Are you using the 6 months s/p treatment end (and is that day of infusion) for live vaccines or a more conservative approach as these kids are usually managed by the BMT team?
    If you can, please share:

    1. Timeline to live vaccines:
    2. Timeline to inactive/attenuated vaccines

    Thank you for sharing!

    Michelle Gillard, MSN, RN, CPHON
    Cellular Therapy Program Coordinator
    Phoenix Children’s Hospital
    Phoenix, AZ