Evidence-Based Practice Clinical Guideline Review

PEP Topic: Prevention of Infection

Author(s): Barbara J. Wilson, MS RN AOCN® ACNS-BC; Falak Ahmed, BScN RN; Courtney E. Crannell, RN-BC MSN OCN®; Wendy Crego, MSN RN OCN® CCRP; Colleen H. Erb, MSN CRNP ACNP-BC AOCNP®; Jacqueline Foster, MPH RN OCN®; Marilyn J. Hammer, PhD DC RN FAAN; Huma Moez, BScN RN; Mary E. Peterson, MS RN ANP-BC AOCNP®; Gail Smith, MSN RN OCN®; Sylvia K. Wood, DNP APRN ANP-BC AOCNP®; and Laura Zitella, MS RN ACNP-BC AOCN®


Method of Review: The Evidence Based Practice Guideline Review Subcommittee conducted a review of the updated guideline using the Rapid Appraisal Checklist for Guidelines by Melnyk.1 Because this guideline was developed using a strict protocol by the Oncology Nursing Society, the subcommittee determined that an additional review using the AGREE criteria was not necessary.

Review Summary: This is an adult based guideline with specific recommendations for patients under 18 years of age. The recommendations cover both the General Oncology and Bone Marrow Transplant settings. Most “recommended for practice” and “likely to be effective” recommendations are applicable to the pediatric population; however, there is limited evidence regarding the use of some drugs (e.g. quinolones) in pediatric patients and drug safety is still a barrier for some recommendations in pediatrics. The Environmental interventions described in this guideline do not address issues specific to pediatrics (e.g. family visitation policies, management of toys and others).

Recommendation for use: Recommended for use with modifications in pediatric oncology.


1Melnyk, B.M. & Fineout-Overholt, E. (2011). Appendix D: Rapid Critical Appraisal Checklist for Evidence Based Clinical Practice Guidelines. In Evidence-Based practice in nursing & healthcare. (2nded.). (p. 518). Philadelphia, PA: Lippincott, Williams & Wilkins.