Clinical Guideline Review

Evidence-Based Management of Sickle Cell Disease: Expert Panel Report

Author(s): An Expert Panel


Method of Review: The APHON Evidence Based Practice/Research Committee conducted a sub-committee group review using the AGREE Criteria for Evaluating Published Guidelines. It was followed by a consensus for approval of the recommendations. This protocol has been endorsed by Expert Panel Report Endorsements Academy of Emergency Medicine (AAEM) American Academy of Pediatrics (AAP) American Academy of Physician Assistants (AAPA) American Osteopathic Association (AOA) American Society of Hematology (ASH) American Society of Pediatric Hematology/Oncology (ASPHO) International Association of Sickle Cell Nurses and Physician Assistants (IASCNAPA) National Black Nurses Association (NBNA) National Initiative for Children’s Health Quality (NICHQ) National Medical Association (NMA) Sickle Cell Disease Association of America (SCDAA).

Review Summary: The purpose of these guidelines is to help people living with sickle cell disease (SCD) receive appropriate care by providing the best science-based recommendations to guide practice decisions. The guidelines provide important recommendations for health maintenance, acute care, and monitoring of various therapies in persons with sickle cell disease. The report was developed by an expert panel comprised of healthcare professionals in family medicine, general internal medicine, adult and pediatric hematology, psychiatry, transfusion medicine, obstetrics and gynecology, emergency department nursing, and evidence based medicine.

Recommendation for use: Recommended for use in pediatric hematology.


1The AGREE Collaboration. Writing Group: Cluzeau FA, Burgers JS, Brouwers M, Grol R, Mäkelä M, Littlejohns P, Grimshaw J, Hunt C. Development and validation of an international appraisal instrument for assessing the quality of clinical practice guidelines: the AGREE project. Quality and Safety in Health Care 2003; 12(1): 18‐23. www.